HitPredict

Interactor 1: MCM2 (P29469)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)
Gene: MCM2

Interactor 2: MCM5 (P29496)
Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46)
Gene: MCM5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 8756666, 23851460, 25172955, 32701054, 37968396, 37850662, 24692448, 25313033, 31728581, 18660534, 19106085, 24875627, 21179020, 24566989
Identification Methods two hybrid, anti bait coimmunoprecipitation, pull down, affinity chromatography technology, protein complementation assay, biochemical, tandem affinity purification, electron microscopy
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MCM~MCM, MCM~MCM_lid, MCM~MCM_N, MCM~MCM_OB, MCM_N~MCM_N, MCM_N~MCM_OB, MCM_OB~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
and 15 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 868
Sc

1 775
+ Hs
+ Sc
+ Dm
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Xl
+ Xl
+ Xl
+ Xl
+ Dm
+ Sp
+ Dm
+ Sp
+ Sc
+ Xl
+ Sp
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024