Interactor 1: NOS1 (P29475)
Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)
Gene: NOS1

Interactor 2: NOS2 (P35228)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FAD_binding_1~FAD_binding_1, FAD_binding_1~Flavodoxin_1, FAD_binding_1~NAD_binding_1, Flavodoxin_1~Flavodoxin_1, Flavodoxin_1~NAD_binding_1, NAD_binding_1~NAD_binding_1, NO_synthase~NO_synthase
Common GO terms GO:0001666 - response to hypoxia
GO:0004517 - nitric-oxide synthase activity
GO:0005516 - calmodulin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 18 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 1434
Hs

1 1153
+ Hs
+ Hs
+ Bt
+ Hs
+ Mm
+ Dm
+ Hs
+ Hs
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024