HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: HDA11 (Q96DB2)
Histone deacetylase 11 (HD11) (EC 3.5.1.98)
Gene: HDAC11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 347
+	Hs
		668659 PML_HUMAN (1-882): 0: 902: 100.00		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89
+	Hs
		668870 PML_HUMAN (1-882): 0: 902: 100.00		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		177209 PML_HUMAN (1-882): 0: 902: 100.00		HDAC3_HUMAN (14-340): 3.7e-128: 375: 20.47
+	Hs
		668851 PML_HUMAN (1-882): 0: 902: 100.00		HDAC7_HUMAN (13-344): 1.91e-121: 373: 19.89
+	Mm
		936397 PML_MOUSE (3-864): 0: 860: 69.34		HDAC2_MOUSE (13-330): 6.36e-128: 376: 22.59
+	Hs
		669040 PML_HUMAN (1-882): 0: 902: 100.00		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31
+	Hs
		177299 Q15156_HUMAN (1-405): 3.39e-81: 280: 97.78		HDAC3_HUMAN (14-340): 3.7e-128: 375: 20.47
+	Hs
		1029390 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89
+	Hs
		880713 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		HDAC4_HUMAN (1-341): 1.28e-127: 393: 20.53
+	Hs
		170356 TIF1A_HUMAN (27-546): 1.94e-62: 231: 16.49		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89
+	Hs
		177283 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		HDAC3_HUMAN (14-340): 3.7e-128: 375: 20.47
+	Dm
		68996 A8WHL4_DROME (1-543): 1.51e-57: 216: 15.45		HDAC1_DROME (8-330): 4.95e-139: 406: 23.74
+	Dm
		1276536 Q9VDK5_DROME (1-543): 3.41e-56: 212: 14.89		HDAC1_DROME (8-330): 4.95e-139: 406: 23.74
+	Hs
		584952 RO52_HUMAN (44-414): 8.03e-56: 202: 13.46		HDAC1_HUMAN (13-330): 8.87e-140: 407: 22.89
+	Hs
		170436 TIF1A_HUMAN (27-546): 1.94e-62: 231: 16.49		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		1052723 TRI25_HUMAN (42-366): 2.13e-54: 201: 16.67		HDAC2_HUMAN (13-330): 4.9e-128: 376: 22.89
+	Hs
		1354158 TRI33_HUMAN (56-558): 4.27e-74: 265: 15.56		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31
+	Hs
		1029704 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		HDA10_HUMAN (16-337): 4.48e-103: 318: 22.35
+	Hs
		1029975 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31
+	Hs
		585087 RO52_HUMAN (44-414): 8.03e-56: 202: 13.46		HDAC6_HUMAN (18-346): 8.68e-95: 307: 21.31