HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: NACC1 (Q96RE7)
Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)
Gene: NACC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25891951
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 527
+	Hs
		669089 PML_HUMAN (1-882): 0: 902: 100.00		KLH20_HUMAN (4-267): 7.84e-69: 234: 17.47
+	Hs
		668731 PML_HUMAN (1-882): 0: 902: 100.00		KLH40_HUMAN (12-261): 3.44e-57: 202: 16.80
+	Hs
		166158 PML_HUMAN (1-882): 0: 902: 100.00		ZBTB5_HUMAN (7-332): 3.13e-50: 184: 18.73
+	Hs
		668486 PML_HUMAN (1-882): 0: 902: 100.00		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Hs
		668620 PML_HUMAN (1-882): 0: 902: 100.00		ZBT16_HUMAN (4-346): 1.57e-48: 180: 20.52
+	Hs
		166065 PML_HUMAN (1-882): 0: 902: 100.00		ZBT39_HUMAN (1-352): 6.52e-43: 164: 18.82
+	Mm
		1113169 PML_MOUSE (3-864): 0: 860: 69.34		Q3UQ17_MOUSE (4-346): 6.72e-53: 192: 20.81
+	Hs
		622095 PML_HUMAN (1-882): 0: 902: 100.00		ZBT25_HUMAN (7-218): 5.91e-38: 146: 24.78
+	Hs
		668794 PML_HUMAN (1-882): 0: 902: 100.00		KAISO_HUMAN (12-139): 5.42e-11: 67: 35.39
+	Hs
		1357688 TRI33_HUMAN (56-558): 4.27e-74: 265: 15.56		KLH20_HUMAN (4-267): 7.84e-69: 234: 17.47
+	Hs
		307212 TRIM8_HUMAN (51-553): 2.61e-68: 239: 14.68		KLHL2_HUMAN (9-322): 4.22e-63: 218: 15.46
+	Hs
		1029406 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		KEAP1_HUMAN (3-260): 7.39e-59: 207: 14.66
+	Hs
		1299554 TRIM2_HUMAN (37-579): 1.33e-55: 207: 13.28		KLHL5_HUMAN (7-291): 4.24e-60: 213: 16.78
+	Hs
		175688 TRI18_HUMAN (48-411): 5.87e-56: 207: 14.22		Q53SE7_HUMAN (21-452): 1.18e-56: 199: 15.27
+	Hs
		175708 TRI18_HUMAN (48-411): 5.87e-56: 207: 14.22		GMCL1_HUMAN (21-452): 1.18e-56: 199: 15.27
+	Dm
		68993 A8WHL4_DROME (1-543): 1.51e-57: 216: 15.45		TTKA_DROME (2-354): 8.8e-43: 165: 15.17
+	Hs
		70958 TRI18_HUMAN (48-411): 5.87e-56: 207: 14.22		ZBT42_HUMAN (7-237): 1.18e-43: 161: 23.83
+	Hs
		1333886 TRI45_HUMAN (57-376): 2.6e-56: 206: 19.38		ZBT40_HUMAN (7-252): 3.02e-41: 161: 19.51
+	Hs
		317642 TRI33_HUMAN (56-558): 4.27e-74: 265: 15.56		ZBT11_HUMAN (10-114): 5.03e-12: 70.9: 38.18
+	Hs
		1029582 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		KAISO_HUMAN (12-139): 5.42e-11: 67: 35.39