HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: SENP1 (Q9P0U3)
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
Gene: SENP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	36880596, 21098080
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016925 - protein sumoylation GO:0031965 - nuclear membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 882 Hs			1 644
+	Hs
		668992 PML_HUMAN (1-882): 0: 902: 100.00		SENP2_HUMAN (139-644): 1.28e-144: 434: 33.46
+	Hs
		668982 PML_HUMAN (1-882): 0: 902: 100.00		SENP3_HUMAN (93-643): 1.85e-109: 343: 22.30
+	Hs
		668908 PML_HUMAN (1-882): 0: 902: 100.00		SENP5_HUMAN (172-644): 1.07e-102: 330: 23.01
+	Hs
		668962 PML_HUMAN (1-882): 0: 902: 100.00		SENP6_HUMAN (534-642): 8.6e-20: 96.2: 22.50
+	Hs
		164494 TRI66_HUMAN (29-540): 6.56e-63: 233: 14.31		SENP1_HUMAN (1-644): 0: 672: 100.00
+	Hs
		1029868 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		SENP3_HUMAN (93-643): 1.85e-109: 343: 22.30
+	Hs
		1029797 TIF1B_HUMAN (7-593): 6.89e-69: 247: 13.97		SENP7_HUMAN (386-643): 2.49e-47: 181: 17.38