HitPredict

Interactor 1: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Interactor 2: OPT (Q9UBM4)
Opticin (Oculoglycan)
Gene: OPTC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1187 Hs			1 332
+	Hs
		337342 ABL1_HUMAN (870-1175): 9.73e-97: 336: 30.74		MIME_HUMAN (102-331): 5.61e-53: 177: 42.61
+	Hs
		522766 SRC_HUMAN (843-1182): 2.67e-99: 328: 28.57		MIME_HUMAN (102-331): 5.61e-53: 177: 42.61
+	Hs
		433494 YES_HUMAN (842-1182): 3.68e-98: 325: 27.91		FLRT1_HUMAN (43-278): 1.69e-28: 117: 24.60
+	Hs
		411826 LCK_HUMAN (879-1183): 1.61e-95: 316: 31.09		ERBIN_HUMAN (155-331): 3.08e-25: 108: 16.76
+	At
		221374 BIK1_ARATH (561-833): 1.44e-93: 307: 18.88		FLS2_ARATH (105-332): 2.49e-25: 108: 16.03
+	Hs
		433956 LYN_HUMAN (890-1179): 2.84e-91: 305: 33.45		ERBIN_HUMAN (155-331): 3.08e-25: 108: 16.76
+	At
		84479 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		GSO1_ARATH (95-331): 4.46e-29: 119: 16.60
+	At
		84744 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		Y4361_ARATH (99-332): 5.8e-26: 110: 19.84
+	At
		85361 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		ERL1_ARATH (2-222): 1.87e-25: 109: 15.09
+	At
		99017 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		RGI4_ARATH (100-332): 1.31e-25: 109: 15.73
+	At
		1278209 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		FLS2_ARATH (105-332): 2.49e-25: 108: 16.03
+	At
		84597 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		RGI3_ARATH (167-329): 1e-19: 92.2: 18.82
+	Hs
		411718 LCK_HUMAN (879-1183): 1.61e-95: 316: 31.09		SCRIB_HUMAN (213-331): 1.8e-09: 60.9: 18.38
+	At
		1278216 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		BRL3_ARATH (128-332): 2.68e-17: 84.8: 16.20
+	Hs
		433758 LYN_HUMAN (890-1179): 2.84e-91: 305: 33.45		SCRIB_HUMAN (213-331): 1.8e-09: 60.9: 18.38
+	At
		1167621 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		ERL2_ARATH (1-157): 2.9e-15: 78.6: 12.42
+	At
		287464 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		SKM1_ARATH (1-170): 2.24e-13: 72.9: 11.17
+	At
		1278223 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		IRK_ARATH (3-139): 8.79e-12: 68.2: 13.48
+	At
		1114696 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		ERECT_ARATH (1-117): 3.89e-10: 62.9: 9.02
+	At
		83975 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		Y1743_ARATH (11-126): 4.97e-09: 59.8: 10.83