HitPredict

Interactor 1: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Interactor 2: PRDX1 (Q06830)
Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	1-cysPrx_C~1-cysPrx_C, 1-cysPrx_C~AhpC-TSA, AhpC-TSA~AhpC-TSA
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006979 - response to oxidative stress GO:0008379 - thioredoxin peroxidase activity GO:0042744 - hydrogen peroxide catabolic process and 1 others more... GO:0045454 - cell redox homeostasis
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 199
+	Hs
		670896 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78
+	Hs
		670892 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		PRDX3_HUMAN (2-197): 1.85e-98: 287: 62.76
+	Hs
		670941 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59
+	Bt
		727701 PRDX3_BOVIN (1-256): 1.68e-120: 345: 88.72		PRDX3_BOVIN (2-197): 5.88e-97: 283: 63.27
+	Mm
		589511 PRDX3_MOUSE (1-256): 4.28e-114: 329: 85.99		PRDX3_MOUSE (2-197): 9.94e-97: 283: 63.27
+	Hs
		685669 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		PRDX1_HUMAN (1-199): 2.21e-105: 302: 100.00
+	Hs
		989277 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		PRDX1_HUMAN (1-199): 2.21e-105: 302: 100.00
+	Hs
		685623 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78
+	Hs
		989269 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		PRDX1_HUMAN (1-199): 2.21e-105: 302: 100.00
+	Mm
		727678 PRDX1_MOUSE (58-253): 2.59e-100: 292: 60.91		PRDX1_MOUSE (1-199): 1.07e-104: 301: 95.48
+	Hs
		1026671 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59
+	Hs
		685676 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59
+	Os
		1150816 BAS1_ORYSJ (1-254): 5.04e-101: 296: 47.51		BAS1_ORYSJ (8-196): 6.91e-87: 258: 57.07
+	At
		1280808 BAS1B_ARATH (43-254): 8.1e-98: 288: 51.40		BAS1A_ARATH (8-196): 2.48e-86: 257: 59.16
+	Sp
		252251 TPX1_SCHPO (61-254): 8.4e-95: 278: 58.76		TPX1_SCHPO (5-198): 2.04e-91: 267: 61.86