HitPredict

Interactor 1: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	21795677, 28225217, 21145461
Identification Methods	affinity chromatography technology, enzymatic study, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 913
+	Hs
		989288 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		989287 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		670946 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		670704 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		1026675 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		685683 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		989286 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		670944 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		670945 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		685681 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		989284 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		670703 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		1026674 PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		685682 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		989285 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL2_HUMAN (205-913): 0: 746: 27.53
+	Hs
		670702 PRDX6_HUMAN (63-254): 3.4e-68: 211: 25.25		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		670991 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		CUL5_HUMAN (213-913): 0: 610: 26.23
+	Hs
		989358 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CUL5_HUMAN (213-913): 0: 610: 26.23