HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 21159657, 24841198, 26496610, 27880917, 10191253, 21460856, 28330616, 18782753, 33856059, 35271311, 34004147, 19156129, 19818709, 22379092, 33961781, 12370081, 17540176, 17632056, 17374643, 23443559 and 11 others

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Identification Methods affinity chromatography technology, proximity labelling technology, pull down, biochemical, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation, two hybrid, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HEAT~Metallophos, HEAT_2~Metallophos
Common GO terms GO:0000159 - protein phosphatase type 2A complex
GO:0000775 - chromosome, centromeric region
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 589
Hs

1 309
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Last updated: 15 Jul 2024