HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 589 Hs			1 768
+	Hs
		672117 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		268709 SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042184 GCN1_HUMAN (28-589): 5.37e-25: 112: 16.01		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042209 TNPO1_HUMAN (24-483): 2.91e-20: 97.2: 15.05		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042127 PP4R1_HUMAN (325-583): 8.14e-09: 60.9: 17.78		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043059 PP4R4_HUMAN (13-411): 1.42e-12: 72.9: 16.71		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		268708 SF3B1_HUMAN (12-589): 2.5e-28: 122: 13.20		CUL1_HUMAN (18-768): 0: 707: 30.57