HitPredict

Interactor 1: 2AAB (P30154)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)
Gene: PPP2R1B

Interactor 2: PP2AB (P62714)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
Gene: PPP2CB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	12370081, 26186194, 26496610, 28514442, 33961781, 35271311, 19156129
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HEAT~Metallophos, HEAT_2~Metallophos
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 601 Hs			1 309
+	Hs
		672079 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		PP2AA_HUMAN (1-309): 0: 533: 97.41
+	Hs
		672072 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		PP2AB_HUMAN (1-309): 0: 532: 100.00
+	Mm
		915332 2AAA_MOUSE (14-601): 2.61e-172: 503: 86.22		PP2AB_MOUSE (1-309): 0: 532: 100.00
+	Mm
		930638 2AAA_MOUSE (14-601): 2.61e-172: 503: 86.22		PP2AA_MOUSE (1-309): 0: 532: 97.41
+	Hs
		672402 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		PP2AA_HUMAN (1-309): 0: 533: 97.41
+	Hs
		672060 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		PP4C_HUMAN (4-309): 0: 511: 64.50
+	Hs
		672395 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		PP4C_HUMAN (4-309): 0: 511: 64.50
+	Dm
		619857 2AAA_DROME (11-590): 7.14e-155: 459: 71.72		PP2A_DROME (1-309): 0: 527: 94.50
+	Hs
		87320 C9J9C1_HUMAN (2-443): 2.87e-41: 160: 21.45		PP2AA_HUMAN (1-309): 0: 533: 97.41
+	Hs
		87319 C9J9C1_HUMAN (2-443): 2.87e-41: 160: 21.45		PP2AB_HUMAN (1-309): 0: 532: 100.00
+	Sp
		619320 2AAA_SCHPO (102-601): 3.34e-48: 179: 19.60		PP2A2_SCHPO (5-309): 0: 507: 79.02
+	Sp
		619310 2AAA_SCHPO (102-601): 3.34e-48: 179: 19.60		PP2A1_SCHPO (7-309): 0: 504: 79.21
+	Sc
		618820 2AAA_YEAST (28-288): 3.04e-14: 77.9: 18.01		PP2A2_YEAST (9-309): 0: 531: 76.08
+	Hs
		890979 PP4R4_HUMAN (287-600): 2.51e-19: 94.5: 16.33		PP4C_HUMAN (4-309): 0: 511: 64.50
+	Hs
		268640 SF3B1_HUMAN (147-580): 4.07e-18: 90.6: 13.84		PP4C_HUMAN (4-309): 0: 511: 64.50
+	Mm
		956531 PP4R4_MOUSE (287-600): 5.1e-18: 90.2: 15.74		PP4C_MOUSE (4-309): 0: 511: 64.50
+	Hs
		268648 SF3B1_HUMAN (147-580): 4.07e-18: 90.6: 13.84		PP1A_HUMAN (5-296): 0: 508: 47.18
+	Sc
		618757 2AAA_YEAST (28-288): 3.04e-14: 77.9: 18.01		PP2A1_YEAST (7-309): 0: 519: 74.92
+	At
		1104838 2AAA_ARATH (339-601): 1.55e-22: 103: 15.59		FYPP1_ARATH (9-309): 2.53e-135: 387: 56.62
+	At
		1105308 2AAG_ARATH (339-601): 3.3e-20: 96.4: 14.07		FYPP1_ARATH (9-309): 2.53e-135: 387: 56.62