HitPredict

Interactor 1: 2AAB (P30154)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)
Gene: PPP2R1B

Interactor 2: 2A5A (Q15172)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)
Gene: PPP2R5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	12370081, 18782753, 33961781, 8703017, 17540176
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	B56~HEAT_2
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019888 - protein phosphatase regulator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 601 Hs			1 486
+	Hs
		672129 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		2A5A_HUMAN (19-486): 0: 734: 100.00
+	Hs
		672123 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		2A5D_HUMAN (12-477): 0: 712: 64.47
+	Hs
		672140 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		2A5E_HUMAN (9-470): 0: 707: 78.36
+	Hs
		672422 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		2A5D_HUMAN (12-477): 0: 712: 64.47
+	Hs
		672130 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		2A5B_HUMAN (2-465): 0: 705: 71.77
+	Hs
		672107 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		2A5G_HUMAN (46-484): 0: 701: 68.32
+	Hs
		672428 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		2A5E_HUMAN (9-470): 0: 707: 78.36
+	Hs
		672187 2AAA_HUMAN (14-601): 3.9e-172: 503: 86.22		Q7L7W2_HUMAN (46-484): 0: 699: 68.32
+	Hs
		672426 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		2A5B_HUMAN (2-465): 0: 705: 71.77
+	Hs
		672415 2AAB_HUMAN (1-601): 8.13e-170: 497: 100.00		2A5G_HUMAN (46-484): 0: 701: 68.32
+	Dm
		734216 2AAA_DROME (11-590): 7.14e-155: 459: 71.72		Q9VEC6_DROME (37-466): 0: 722: 64.90
+	Dm
		47131 2AAA_DROME (11-590): 7.14e-155: 459: 71.72		A0A6F7R657_DROME (4-466): 0: 712: 71.98
+	Dm
		734212 2AAA_DROME (11-590): 7.14e-155: 459: 71.72		Q9VB23_DROME (47-466): 0: 702: 77.91
+	Ce
		999428 2AAA_CAEEL (102-601): 3.82e-44: 168: 17.26		Q17948_CAEEL (14-466): 0: 697: 59.61
+	Ce
		110946 2AAA_CAEEL (102-601): 3.82e-44: 168: 17.26		H9G2X3_CAEEL (14-466): 0: 695: 59.61
+	Ce
		999433 2AAA_CAEEL (102-601): 3.82e-44: 168: 17.26		Q9U3Q1_CAEEL (33-466): 0: 695: 61.73
+	At
		1104795 2AAA_ARATH (339-601): 1.55e-22: 103: 15.59		2A5G_ARATH (38-470): 0: 720: 49.09
+	At
		138268 2AAA_ARATH (339-601): 1.55e-22: 103: 15.59		2A5B_ARATH (2-465): 0: 698: 48.41
+	Sp
		945006 2AAA_SCHPO (102-601): 3.34e-48: 179: 19.60		2AD2_SCHPO (4-465): 0: 605: 48.50
+	Ca
		1124091 Q5ADN1_CANAL (143-600): 4.79e-35: 142: 19.40		Q59Q44_CANAL (37-403): 3.07e-154: 461: 59.14