HitPredict

Interactor 1: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Interactor 2: Q5T8C6 (Q5T8C6)
Cell division cycle 16
Gene: CDC16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	ANAPC3~TPR_12, TPR_1~TPR_12, TPR_12~TPR_8
Common GO terms	GO:0005680 - anaphase-promoting complex GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0031145 - anaphase-promoting complex-dependent catabolic process GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 824 Hs			1 475
+	Hs
		672822 CDC27_HUMAN (1-824): 0: 625: 100.00		CDC16_HUMAN (1-475): 5.47e-91: 291: 89.73
+	Xl
		1150241 Q6GQ04_XENLA (1-824): 0: 570: 89.09		Q6DFI7_XENLA (1-475): 2.76e-83: 271: 78.26
+	Hs
		672772 CDC27_HUMAN (1-824): 0: 625: 100.00		CDC27_HUMAN (13-392): 3.12e-35: 141: 11.29
+	Hs
		672917 CDC27_HUMAN (1-824): 0: 625: 100.00		APC7_HUMAN (28-450): 1.26e-15: 81.1: 12.44
+	Hs
		672916 CDC27_HUMAN (1-824): 0: 625: 100.00		CDC23_HUMAN (40-416): 1.4e-09: 62.2: 10.85
+	Mm
		56872 CDC27_MOUSE (1-824): 0: 607: 96.97		APC7_MOUSE (43-450): 1.44e-14: 78: 12.17
+	Xl
		1151584 Q6GQ04_XENLA (1-824): 0: 570: 89.09		Q7T0N9_XENLA (9-351): 1.92e-20: 96.1: 14.20
+	Xl
		1151586 Q6GQ04_XENLA (1-824): 0: 570: 89.09		Q8AVF0_XENLA (29-385): 8.49e-20: 94.1: 9.29
+	Xl
		1150214 Q6GQ04_XENLA (1-824): 0: 570: 89.09		Q6DDX5_XENLA (138-440): 1.6e-09: 62.2: 9.95
+	Hs
		1022909 Q4KMX6_HUMAN (290-823): 1.11e-60: 217: 16.28		CDC16_HUMAN (1-475): 5.47e-91: 291: 89.73
+	Hs
		1023016 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		CDC16_HUMAN (1-475): 5.47e-91: 291: 89.73
+	Dm
		1363028 Q9VS37_DROME (3-778): 4.41e-122: 391: 37.90		Q9VCN6_DROME (28-381): 5.36e-23: 104: 18.34
+	Hs
		175291 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		OGT1_HUMAN (106-463): 1.83e-45: 172: 14.89
+	At
		1280893 SPY_ARATH (505-822): 3.09e-58: 216: 13.86		SPY_ARATH (10-260): 6.09e-23: 104: 5.46
+	Sp
		293620 APC8_SCHPO (475-785): 2.47e-59: 213: 21.84		APC8_SCHPO (24-423): 4.83e-19: 91.9: 11.98
+	Hs
		1356132 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		APC7_HUMAN (28-450): 1.26e-15: 81.1: 12.44
+	Hs
		1356109 APC7_HUMAN (290-823): 9.27e-61: 217: 16.28		CDC23_HUMAN (40-416): 1.4e-09: 62.2: 10.85