HitPredict

Interactor 1: CCND2 (P30279)
G1/S-specific cyclin-D2
Gene: CCND2

Interactor 2: CDN1B (P46527)
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Gene: CDKN1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.952

The method score is based on:

Property Details
Experiments 10022865, 26186194, 16189514, 28514442, 33961781, 25910212
Identification Methods affinity chromatography technology, two hybrid, split luciferase complementation, two hybrid bait and prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Cyclin_N
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001934 - positive regulation of protein phosphorylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 289
Hs

1 198
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Last updated: 15 Jul 2024