HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 323
+	Hs
		622375 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		538485 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Mm
		624389 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Mm
		673184 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		905830 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Mm
		629209 CCND1_MOUSE (2-292): 1.72e-85: 259: 51.86		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		622421 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Mm
		906272 CCNA1_MOUSE (7-284): 1.94e-90: 276: 25.00		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		538508 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		673135 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Mm
		624387 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Mm
		673182 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		538509 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		673136 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Mm
		624388 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1B_MOUSE (1-322): 0: 560: 86.89
+	Mm
		673183 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1B_MOUSE (1-322): 0: 560: 86.89
+	Hs
		915161 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		PP2AB_HUMAN (8-312): 2.02e-178: 497: 46.73
+	Hs
		673059 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		PP2AA_HUMAN (8-312): 5.65e-178: 496: 46.08