HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 23880157, 25416956, 26186194, 16189514, 28514442, 30217970, 32296183, 23737759, 34591612, 9716181, 8756624, 15232106, 21988832, 26496610, 27107012, 30833792, 33961781, 23443559, 31515488, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, barcode fusion genetics two hybrid, protein array, mammalian protein protein interaction trap and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Cyclin_N
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001934 - positive regulation of protein phosphorylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 292
Hs

1 164
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024