HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 168
+	Hs
		622390 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00
+	Hs
		673134 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		CDN2D_HUMAN (6-159): 4e-48: 155: 45.81
+	Hs
		673036 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00
+	Hs
		622389 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		276144 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		PSD10_HUMAN (1-110): 7.59e-30: 110: 24.32
+	Hs
		673034 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Mm
		629214 CCND1_MOUSE (2-292): 1.72e-85: 259: 51.86		EHMT1_MOUSE (8-84): 1.14e-15: 75.3: 20.51
+	Hs
		673035 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		303856 CCNB2_HUMAN (2-285): 2.8e-84: 260: 22.38		MIB1_HUMAN (74-168): 4.43e-14: 70.7: 21.88
+	Hs
		624560 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00
+	Hs
		624558 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		624559 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22