HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 34591612
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 316
+	Hs
		622403 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		622378 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		538496 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		590146 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		758186 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		622395 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		622511 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		Q96TE0_HUMAN (9-201): 1.11e-24: 100: 21.76
+	Mm
		763418 CCNA1_MOUSE (7-284): 1.94e-90: 276: 25.00		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		538489 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		590139 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		804103 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		624384 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		673127 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Mm
		803837 CCNA2_MOUSE (1-285): 1.54e-86: 266: 26.57		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		538492 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		673180 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		590142 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		673130 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		1146034 Q66J45_XENLA (8-284): 8.51e-88: 269: 26.43		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Xl
		1151481 Q6GME9_XENLA (6-284): 2.59e-87: 268: 25.36		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46