HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 25416956, 26186194, 28514442, 30217970, 29997244, 26264872, 33854235, 33961781, 23737759, 34591612, 9716181, 16782892, 15232106, 21516116, 27107012, 32296183, 11360184, 8114739, 32707033, 17517622 and 4 others

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Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, pull down, anti bait coimmunoprecipitation, mammalian protein protein interaction trap, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation, validated two hybrid, two hybrid prey pooling approach and 5 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005634 - nucleus
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 292
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024