HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	26186194, 28514442, 32296183, 33961781, 34591612, 23602568, 23455922, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, validated two hybrid, two hybrid array, two hybrid prey pooling approach, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0004693 - cyclin-dependent protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 292
+	Hs
		622358 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		622427 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		622429 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414742 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	At
		621690 CCA11_ARATH (1-287): 2.15e-98: 298: 23.10		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		621689 CCA32_ARATH (3-287): 5.53e-99: 296: 21.72		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		621697 CCA31_ARATH (10-292): 6.46e-97: 291: 21.95		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		621662 CCA21_ARATH (2-280): 1.56e-95: 290: 24.47		CDKA1_ARATH (1-289): 1.76e-134: 383: 55.82
+	At
		1319943 CCA32_ARATH (3-287): 5.53e-99: 296: 21.72		CDKD1_ARATH (2-292): 1.36e-129: 375: 49.14
+	At
		1320044 CCA11_ARATH (1-287): 2.15e-98: 298: 23.10		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	At
		1319944 CCA32_ARATH (3-287): 5.53e-99: 296: 21.72		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	At
		1324476 CCA31_ARATH (10-292): 6.46e-97: 291: 21.95		CDKD3_ARATH (2-292): 2.44e-126: 366: 47.77
+	At
		1227951 CCA11_ARATH (1-287): 2.15e-98: 298: 23.10		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		1103369 CCA31_ARATH (10-292): 6.46e-97: 291: 21.95		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	At
		1103352 CCA21_ARATH (2-280): 1.56e-95: 290: 24.47		CKB12_ARATH (1-289): 1.61e-123: 356: 50.97
+	At
		639357 CCA11_ARATH (1-287): 2.15e-98: 298: 23.10		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98
+	At
		1227954 CCA31_ARATH (10-292): 6.46e-97: 291: 21.95		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		1106945 CCA21_ARATH (2-280): 1.56e-95: 290: 24.47		CKB21_ARATH (1-290): 1.28e-121: 352: 48.00
+	At
		639364 CCA31_ARATH (10-292): 6.46e-97: 291: 21.95		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98
+	At
		639343 CCA21_ARATH (2-280): 1.56e-95: 290: 24.47		CKB11_ARATH (1-289): 3.38e-120: 348: 50.98