HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN2C (Q60772)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: Cdkn2c

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	17713536
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 168
+	Hs
		625621 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		RAI14_HUMAN (1-135): 3.66e-36: 134: 23.53
+	Hs
		515365 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2C_HUMAN (1-168): 2.81e-52: 165: 92.26
+	Hs
		790967 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2C_HUMAN (1-168): 2.81e-52: 165: 92.26
+	Mm
		1141372 CDK6_MOUSE (5-303): 4.02e-128: 369: 67.67		CDN2D_MOUSE (6-161): 1.24e-46: 151: 44.59
+	Mm
		673235 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2D_MOUSE (6-161): 1.24e-46: 151: 44.59
+	Hs
		515390 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2D_HUMAN (6-162): 6.87e-46: 149: 43.67
+	Hs
		877470 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2D_HUMAN (6-162): 6.87e-46: 149: 43.67
+	Hs
		276137 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		PSD10_HUMAN (1-110): 2.01e-29: 109: 25.23
+	Mm
		673242 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		PSD10_MOUSE (1-110): 3.35e-29: 108: 25.23
+	Hs
		515363 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2A_HUMAN (3-140): 1.67e-22: 89.4: 40.29
+	Hs
		790748 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2A_HUMAN (3-140): 1.67e-22: 89.4: 40.29
+	Mm
		673230 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2B_MOUSE (9-127): 7.83e-22: 87: 43.33
+	Hs
		515364 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2B_HUMAN (9-127): 1.38e-21: 86.7: 45.00
+	Hs
		790922 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2B_HUMAN (9-127): 1.38e-21: 86.7: 45.00
+	Mm
		673228 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2A_MOUSE (15-122): 2.57e-20: 84: 44.04