HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: UCHL1 (Q9R0P9)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23543736
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 223
+	Hs
		456499 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		414694 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		456480 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		456547 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Mm
		509494 CDK1_MOUSE (3-300): 1.05e-128: 370: 42.24		UCHL1_MOUSE (1-223): 1.11e-101: 295: 100.00
+	Hs
		456548 CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		415011 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		BAP1_HUMAN (3-220): 4.12e-78: 250: 22.69