HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	10775038, 36931259, 15324660, 17353931
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 246
+	Hs
		673261 WEE1_HUMAN (1-646): 0: 530: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		673263 WEE1_HUMAN (1-646): 0: 530: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		646654 WEE1_HUMAN (1-646): 0: 530: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		673260 WEE1_HUMAN (1-646): 0: 530: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		673268 WEE1_HUMAN (1-646): 0: 530: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		673248 WEE1_HUMAN (1-646): 0: 530: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	At
		965291 CDPK1_ARATH (135-645): 2.74e-128: 393: 16.17		14332_ARATH (1-241): 4.75e-145: 407: 63.27
+	At
		802001 CDPK1_ARATH (135-645): 2.74e-128: 393: 16.17		14334_ARATH (2-241): 1.74e-141: 398: 61.07
+	Hs
		681770 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		681776 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		909532 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Mm
		926819 KCC2D_MOUSE (293-630): 2.17e-106: 332: 21.25		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Hs
		683826 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Mm
		659446 KCC2B_MOUSE (293-643): 2.27e-102: 324: 23.27		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Hs
		681766 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		647391 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		681682 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		904532 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		684020 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		684406 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62