HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

Property	Details
Experiments	35271311, 36931259, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, far western blotting
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 646 Hs			1 245
+	Hs
		673261 WEE1_HUMAN (1-646): 0: 530: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646654 WEE1_HUMAN (1-646): 0: 530: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		673247 WEE1_HUMAN (1-646): 0: 530: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		673260 WEE1_HUMAN (1-646): 0: 530: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		673268 WEE1_HUMAN (1-646): 0: 530: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		673248 WEE1_HUMAN (1-646): 0: 530: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	At
		965291 CDPK1_ARATH (135-645): 2.74e-128: 393: 16.17		14332_ARATH (3-239): 6.89e-143: 401: 65.15
+	At
		802001 CDPK1_ARATH (135-645): 2.74e-128: 393: 16.17		14334_ARATH (3-239): 1.97e-140: 396: 63.07
+	Hs
		681776 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		681770 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Mm
		926819 KCC2D_MOUSE (293-630): 2.17e-106: 332: 21.25		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		909532 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Mm
		659446 KCC2B_MOUSE (293-643): 2.27e-102: 324: 23.27		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		647391 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683826 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		681766 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		681682 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		904532 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		684020 KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		684406 KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97