HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	22885324
Identification Methods	protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 126
+	Hs
		617927 AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420807 AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		682181 AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		682137 AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		277601 PAK3_HUMAN (3-592): 1.19e-123: 379: 19.24		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Mm
		682111 AKT1_MOUSE (181-634): 8.33e-124: 377: 16.17		H2B2B_MOUSE (1-126): 2.34e-54: 168: 97.62
+	Hs
		241401 PAK3_HUMAN (3-592): 1.19e-123: 379: 19.24		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		617926 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Mm
		682113 AKT1_MOUSE (181-634): 8.33e-124: 377: 16.17		H2B1C_MOUSE (1-126): 1.18e-53: 166: 99.21
+	Hs
		420806 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		681878 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		682194 AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		681686 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		681937 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1087363 PMYT1_HUMAN (289-569): 3.54e-33: 135: 34.59		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1023051 STK4_HUMAN (286-572): 1.36e-17: 88.2: 26.89		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Sc
		355424 SWE1_YEAST (289-531): 1.88e-16: 85.5: 28.52		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55