HitPredict

Interactor 1: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	25900982, 30067982, 15070733
Identification Methods	proximity labelling technology, affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 605
+	Hs
		673304 WEE1_HUMAN (1-646): 0: 530: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		682082 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		673289 WEE1_HUMAN (1-646): 0: 530: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		681967 AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1023143 STK4_HUMAN (286-572): 1.36e-17: 88.2: 26.89		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1027457 STK3_HUMAN (274-572): 5.91e-17: 86.3: 25.79		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Dm
		1213409 AKT1_DROME (62-635): 4.8e-129: 395: 15.68		NLE_DROME (218-531): 8.76e-63: 216: 20.22
+	Dm
		218248 AKT1_DROME (62-635): 4.8e-129: 395: 15.68		O44382_DROME (466-605): 2.38e-30: 127: 29.37
+	Dm
		1213390 AKT1_DROME (62-635): 4.8e-129: 395: 15.68		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		1023136 STK4_HUMAN (286-572): 1.36e-17: 88.2: 26.89		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1027451 STK3_HUMAN (274-572): 5.91e-17: 86.3: 25.79		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1027412 STK3_HUMAN (274-572): 5.91e-17: 86.3: 25.79		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Sp
		428847 WEE1_SCHPO (297-559): 4.52e-23: 106: 29.51		POF1_SCHPO (492-604): 1.64e-21: 100: 27.19
+	Sc
		701875 SWE1_YEAST (289-531): 1.88e-16: 85.5: 28.52		MET30_YEAST (530-604): 1.34e-09: 63.1: 20.00