HitPredict

Interactor 1: HLAF (P30511)
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)
Gene: HLA-F

Interactor 2: CL12B (Q2HXU8)
C-type lectin domain family 12 member B (Macrophage antigen H)
Gene: CLEC12B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0009897 - external side of plasma membrane GO:0045953 - negative regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 346 Hs			1 276
+	Hs
		382559 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC4E_HUMAN (132-265): 9.34e-41: 142: 31.21
+	Hs
		382490 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC4D_HUMAN (119-264): 1.01e-39: 139: 24.52
+	Hs
		382491 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC2B_HUMAN (130-266): 8.29e-41: 139: 32.12
+	Hs
		488269 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4G_HUMAN (58-269): 6.35e-48: 163: 23.39
+	Hs
		354602 HLAB_HUMAN (1-345): 2.86e-153: 436: 79.71		CLC4E_HUMAN (132-265): 9.34e-41: 142: 31.21
+	Hs
		570305 HLAG_HUMAN (1-335): 9.94e-155: 439: 79.10		NKG2A_HUMAN (3-267): 2.06e-35: 128: 22.47
+	Hs
		354302 HLAB_HUMAN (1-345): 2.86e-153: 436: 79.71		NKG2A_HUMAN (3-267): 2.06e-35: 128: 22.47
+	Hs
		488420 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4E_HUMAN (132-265): 9.34e-41: 142: 31.21
+	Hs
		354435 HLAB_HUMAN (1-345): 2.86e-153: 436: 79.71		KLRD1_HUMAN (136-267): 1.05e-35: 127: 31.82
+	Hs
		674000 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CLC4E_HUMAN (132-265): 9.34e-41: 142: 31.21
+	Hs
		488317 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4D_HUMAN (119-264): 1.01e-39: 139: 24.52
+	Hs
		488322 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC2B_HUMAN (130-266): 8.29e-41: 139: 32.12
+	Hs
		673971 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CLC2B_HUMAN (130-266): 8.29e-41: 139: 32.12
+	Hs
		533155 HLAE_HUMAN (17-330): 2.38e-143: 411: 73.57		CLC2B_HUMAN (130-266): 8.29e-41: 139: 32.12
+	Hs
		488205 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		KLRD1_HUMAN (136-267): 1.05e-35: 127: 31.82
+	Hs
		673995 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CLC2D_HUMAN (143-266): 1.26e-35: 128: 29.03
+	Hs
		533124 HLAE_HUMAN (17-330): 2.38e-143: 411: 73.57		NKG2A_HUMAN (3-267): 2.06e-35: 128: 22.47
+	Hs
		533144 HLAE_HUMAN (17-330): 2.38e-143: 411: 73.57		KLRD1_HUMAN (136-267): 1.05e-35: 127: 31.82
+	Hs
		533125 HLAE_HUMAN (17-330): 2.38e-143: 411: 73.57		NKG2C_HUMAN (138-267): 3.19e-33: 123: 31.54
+	Hs
		570381 HLAG_HUMAN (1-335): 9.94e-155: 439: 79.10		MRC2_HUMAN (165-272): 3.99e-14: 74.1: 18.18