HitPredict

Interactor 1: HLAF (P30511)
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)
Gene: HLA-F

Interactor 2: CLC4E (Q9ULY5)
C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE)
Gene: CLEC4E

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0016020 - membrane GO:0030670 - phagocytic vesicle membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 219
+	Hs
		382559 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		382490 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC4D_HUMAN (7-208): 1.74e-60: 190: 36.84
+	Hs
		354602 HLAB_HUMAN (1-345): 2.86e-153: 436: 79.71		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		488420 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		382561 HLAA_HUMAN (1-345): 1.49e-170: 480: 80.29		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		488317 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4D_HUMAN (7-208): 1.74e-60: 190: 36.84
+	Hs
		488421 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		674001 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		1278673 HMR1_HUMAN (5-343): 5.88e-114: 335: 38.01		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		488269 HLAC_HUMAN (1-308): 1.76e-147: 422: 80.20		CLC4G_HUMAN (61-207): 1.57e-35: 128: 33.78
+	Hs
		673960 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CL12B_HUMAN (55-207): 2.11e-34: 125: 29.68
+	Hs
		570381 HLAG_HUMAN (1-335): 9.94e-155: 439: 79.10		MRC2_HUMAN (92-215): 1.99e-12: 67.8: 19.05
+	Hs
		673995 HLAF_HUMAN (1-346): 1.25e-147: 421: 100.00		CLC2D_HUMAN (67-169): 2.71e-11: 62: 35.24