HitPredict

Interactor 1: V2R (P30518)
Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)
Gene: AVPR2

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12473660
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0030139 - endocytic vesicle
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 371 Hs			1 409
+	Hs
		428933 ADRB2_HUMAN (1-364): 8.97e-80: 252: 18.82		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (12-362): 1.03e-78: 249: 18.38		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		208441 OX1R_HUMAN (8-371): 5.39e-75: 239: 22.22		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		441648 ADRB1_HUMAN (2-362): 1.08e-71: 232: 19.85		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685813 APJ_HUMAN (21-367): 2.05e-66: 216: 20.50		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		208444 OX1R_HUMAN (8-371): 5.39e-75: 239: 22.22		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		685822 OPRD_HUMAN (2-363): 3.48e-64: 210: 23.22		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		441649 ADRB1_HUMAN (2-362): 1.08e-71: 232: 19.85		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		781016 OPRD_HUMAN (2-363): 3.48e-64: 210: 23.22		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Dm
		115381 M9PF00_DROME (3-328): 3.15e-80: 259: 24.10		Q9V393_DROME (3-402): 0: 594: 57.48
+	Hs
		685848 AGTR2_HUMAN (103-340): 2.63e-11: 66.2: 26.46		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663942 GNRHR_RAT (41-329): 2.69e-22: 97.8: 27.52		ARRB1_RAT (1-399): 0: 654: 76.90