HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: EFNB1 (P98172)
Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
Gene: EFNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 346
+	Hs
		665390 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNB1_HUMAN (1-346): 0: 538: 100.00
+	Hs
		665381 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Hs
		856510 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNB2_HUMAN (8-346): 1.88e-155: 441: 55.39
+	Mm
		856591 EPHA4_MOUSE (2-836): 0: 636: 19.66		EFNB2_MOUSE (2-346): 1.02e-154: 439: 54.16
+	Dr
		251124 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		EFNB2_DANRE (8-346): 9.92e-147: 418: 51.01
+	Dr
		1140993 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		Q90Z31_DANRE (13-346): 2.58e-138: 397: 45.53
+	Hs
		872654 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNB3_HUMAN (33-346): 6.4e-107: 318: 41.28
+	Hs
		595975 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNA1_HUMAN (11-175): 6.64e-66: 208: 31.40
+	Hs
		665379 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNA3_HUMAN (31-220): 3.31e-63: 202: 21.57
+	Dr
		47532 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		A0A8M1Q1X6_DANRE (14-210): 2.08e-59: 192: 23.92
+	Hs
		595985 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNA1_HUMAN (11-175): 6.64e-66: 208: 31.40
+	Dr
		945416 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		EFNA5_DANRE (13-149): 3.11e-58: 189: 29.53
+	Hs
		665382 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Dr
		945415 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		EFNA2_DANRE (16-189): 1.14e-57: 186: 23.89
+	Mm
		139054 Q8BRB1_MOUSE (2-831): 0: 640: 19.00		EFNA5_MOUSE (13-199): 4.54e-60: 194: 26.13
+	Dr
		1140992 Q5ZEW1_DANRE (2-841): 0: 654: 19.73		Q90YC5_DANRE (30-210): 1e-53: 177: 25.53
+	Hs
		856597 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNA5_HUMAN (13-199): 3.51e-60: 194: 26.63
+	Hs
		665380 EPHA3_HUMAN (2-831): 0: 646: 19.34		EFNA4_HUMAN (13-211): 5.6e-53: 175: 23.42
+	Hs
		856348 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNA4_HUMAN (13-211): 5.6e-53: 175: 23.42
+	Hs
		217636 EPHA4_HUMAN (2-836): 0: 637: 19.40		EFNA2_HUMAN (25-142): 1.12e-46: 159: 32.31