HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	19815557
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016310 - phosphorylation GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 894 Hs			1 1038
+	Hs
		674559 UFO_HUMAN (1-894): 0: 780: 100.00		ERRFI_HUMAN (445-889): 3.2e-139: 427: 30.21
+	Hs
		674354 UFO_HUMAN (1-894): 0: 780: 100.00		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		522808 UFO_HUMAN (1-894): 0: 780: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Mm
		70553 UFO_MOUSE (8-894): 0: 745: 88.29		B2RQ57_MOUSE (1-845): 2.76e-132: 429: 22.12
+	Hs
		411613 UFO_HUMAN (1-894): 0: 780: 100.00		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		337359 EPHA3_HUMAN (2-831): 0: 646: 19.34		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		665374 EPHA3_HUMAN (2-831): 0: 646: 19.34		EPHB2_HUMAN (10-539): 5.4e-127: 414: 21.60
+	Hs
		665385 EPHA3_HUMAN (2-831): 0: 646: 19.34		EPHA4_HUMAN (84-486): 5.91e-125: 407: 23.98
+	Hs
		789049 EPHA4_HUMAN (2-836): 0: 637: 19.40		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		665568 EPHA4_HUMAN (2-836): 0: 637: 19.40		EPHB2_HUMAN (10-539): 5.4e-127: 414: 21.60
+	Hs
		522802 EPHA3_HUMAN (2-831): 0: 646: 19.34		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412036 EPHA3_HUMAN (2-831): 0: 646: 19.34		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		522871 EPHA4_HUMAN (2-836): 0: 637: 19.40		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412105 EPHA4_HUMAN (2-836): 0: 637: 19.40		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		665383 EPHA3_HUMAN (2-831): 0: 646: 19.34		EPHA5_HUMAN (109-396): 1.35e-108: 364: 33.33
+	Hs
		665399 EPHA3_HUMAN (2-831): 0: 646: 19.34		EPHA7_HUMAN (109-395): 5.69e-109: 364: 32.77
+	Hs
		433602 EPHA3_HUMAN (2-831): 0: 646: 19.34		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		433662 EPHA4_HUMAN (2-836): 0: 637: 19.40		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		337998 UFO_HUMAN (1-894): 0: 780: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58