HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: MERTK (Q12866)
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Gene: MERTK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.767

The method score is based on:

Property Details
Experiments 35384245, 9160883
Identification Methods affinity chromatography technology, surface plasmon resonance
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains fn3~fn3, fn3~ig, Ig_3~fn3, PK_Tyr_Ser-Thr~fn3, Ig_3~ig, Ig_3~Ig_3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001779 - natural killer cell differentiation
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
and 13 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 894
Hs

1 999
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Last updated: 15 Jul 2024