HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 694
+	Hs
		872642 EPHA4_HUMAN (2-836): 0: 637: 19.40		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872436 EPHA5_HUMAN (2-812): 0: 622: 20.39		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665596 EPHB2_HUMAN (2-837): 0: 605: 19.58		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665234 EPHA2_HUMAN (3-837): 0: 604: 19.66		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		674531 UFO_HUMAN (1-894): 0: 780: 100.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872491 EPHA5_HUMAN (2-812): 0: 622: 20.39		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1072602 EPHA7_HUMAN (2-837): 0: 621: 19.50		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		665661 EPHB2_HUMAN (2-837): 0: 605: 19.58		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		600673 EPHA1_HUMAN (1-837): 0: 555: 20.58		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		441499 MET_HUMAN (536-799): 3.42e-66: 243: 45.90		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		101608 F8VQL0_MOUSE (536-799): 5.83e-66: 243: 45.90		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Mm
		555049 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		600712 EPHA1_HUMAN (1-837): 0: 555: 20.58		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33
+	Hs
		872712 EPHA4_HUMAN (2-836): 0: 637: 19.40		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872492 EPHA5_HUMAN (2-812): 0: 622: 20.39		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		1072603 EPHA7_HUMAN (2-837): 0: 621: 19.50		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665662 EPHB2_HUMAN (2-837): 0: 605: 19.58		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		441588 MET_HUMAN (536-799): 3.42e-66: 243: 45.90		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		411498 INSR_HUMAN (272-851): 1.65e-136: 443: 27.97		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Mm
		57145 MET_MOUSE (536-799): 5.47e-66: 243: 45.90		A2AI78_MOUSE (7-320): 1.74e-53: 200: 18.94