HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: ERBIN (Q96RT1)
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)
Gene: ERBIN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	35022314, 35384245
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~fn3, Ig_3~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 894 Hs			1 1412
+	Hs
		665420 EPHA3_HUMAN (2-831): 0: 646: 19.34		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		872694 EPHA4_HUMAN (2-836): 0: 637: 19.40		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		872473 EPHA5_HUMAN (2-812): 0: 622: 20.39		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		1072577 EPHA7_HUMAN (2-837): 0: 621: 19.50		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		665318 EPHA2_HUMAN (3-837): 0: 604: 19.66		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		601574 FGFR2_HUMAN (27-239): 5.42e-33: 139: 14.46		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		169196 MUSK_HUMAN (2-147): 3.72e-14: 79: 11.26		ERBIN_HUMAN (8-1412): 0: 907: 100.00
+	Hs
		674422 UFO_HUMAN (1-894): 0: 780: 100.00		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		674530 UFO_HUMAN (1-894): 0: 780: 100.00		LRC40_HUMAN (23-355): 2.71e-15: 83.2: 24.67
+	Hs
		1049958 EPHA7_HUMAN (2-837): 0: 621: 19.50		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		665600 EPHB2_HUMAN (2-837): 0: 605: 19.58		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		441501 MET_HUMAN (536-799): 3.42e-66: 243: 45.90		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		169176 MUSK_HUMAN (2-147): 3.72e-14: 79: 11.26		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		507995 FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		435639 IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07		SCRIB_HUMAN (357-1409): 1.57e-40: 166: 12.00
+	Hs
		508286 FGFR1_HUMAN (10-149): 2.65e-12: 72.9: 15.69		MFHA1_HUMAN (74-407): 3.23e-28: 125: 30.27
+	Hs
		169200 MUSK_HUMAN (2-147): 3.72e-14: 79: 11.26		LRRC1_HUMAN (311-709): 1.39e-23: 108: 15.97