HitPredict

Interactor 1: AMRP (P30533)
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)
Gene: LRPAP1

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.949

Property	Details
Experiments	11294867, 28514442, 8940146, 11557679, 33961781, 26858303
Identification Methods	pull down, affinity chromatography technology, biochemical, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Alpha-2-MRAP_C~Ldl_recept_a, Alpha-2-MRAP_N~Ldl_recept_a
Common GO terms	GO:0001540 - amyloid-beta binding GO:0005768 - endosome GO:0005783 - endoplasmic reticulum GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 1 others more... GO:0009986 - cell surface
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 357 Hs			1 2214
+	Hs
		674713 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		SORT_HUMAN (60-756): 7.38e-180: 572: 28.88
+	Hs
		351054 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LDLR_HUMAN (1077-1278): 2.77e-29: 129: 34.48
+	Hs
		674650 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		VLDLR_HUMAN (1457-1575): 6.38e-21: 102: 28.57
+	Hs
		674662 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP8_HUMAN (1323-1699): 1.23e-19: 98.5: 19.36
+	Hs
		254247 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP4_HUMAN (1350-1709): 2.47e-19: 98.1: 15.51
+	Hs
		674651 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP2_HUMAN (1316-1712): 1.36e-18: 95.8: 17.49
+	Hs
		674731 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP1B_HUMAN (1311-1577): 6.86e-10: 66.9: 10.37
+	Hs
		674653 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP1_HUMAN (1196-1349): 2.92e-09: 65: 28.32
+	Gg
		223337 O57378_CHICK (27-357): 1.68e-131: 381: 67.87		VLDLR_CHICK (1462-1575): 7.52e-20: 99.1: 30.70
+	Gg
		223338 O57378_CHICK (27-357): 1.68e-131: 381: 67.87		LRP8_CHICK (977-1204): 6.56e-12: 73.1: 16.67
+	Dm
		65980 Q9VH64_DROME (15-357): 2.22e-98: 298: 31.84		A8JRC4_DROME (1419-1554): 2.46e-16: 87.8: 39.73