HitPredict

Interactor 1: AMRP (P30533)
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)
Gene: LRPAP1

Interactor 2: LRP1B (Q9NZR2)
Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)
Gene: LRP1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Alpha-2-MRAP_C~Ldl_recept_a, Alpha-2-MRAP_N~Ldl_recept_a
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 357 Hs			1 4599
+	Hs
		674705 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		SORL_HUMAN (4318-4575): 1.89e-12: 76.8: 11.24
+	Hs
		674650 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		VLDLR_HUMAN (4316-4573): 2.68e-12: 75.6: 12.73
+	Hs
		351054 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LDLR_HUMAN (30-277): 8.85e-12: 74.1: 17.72
+	Hs
		674651 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP2_HUMAN (4299-4586): 2.33e-10: 69.9: 9.18
+	Hs
		674662 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP8_HUMAN (4088-4430): 1.39e-09: 66.8: 9.81
+	Hs
		254247 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP4_HUMAN (3711-3893): 9.84e-09: 64.5: 21.29
+	Hs
		674653 AMRP_HUMAN (1-357): 5.38e-152: 433: 100.00		LRP1_HUMAN (5-268): 9.9e-09: 64.5: 14.24
+	Gg
		223337 O57378_CHICK (27-357): 1.68e-131: 381: 67.87		VLDLR_CHICK (3224-3467): 5.33e-11: 71.4: 20.57
+	Gg
		223338 O57378_CHICK (27-357): 1.68e-131: 381: 67.87		LRP8_CHICK (31-245): 3.67e-09: 65.2: 18.42
+	Dm
		65980 Q9VH64_DROME (15-357): 2.22e-98: 298: 31.84		A8JRC4_DROME (4102-4367): 4.94e-09: 65.2: 14.98