HitPredict

Interactor 1: AGTR1 (P30556)
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Gene: AGTR1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	33339432, 28298427, 11226259, 15611106
Identification Methods	fluorescent resonance energy transfer, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0060326 - cell chemotaxis
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 409
+	Rn
		626614 AGTRA_RAT (1-359): 3.03e-89: 274: 94.71		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		674834 AGTR1_HUMAN (1-359): 5.59e-90: 276: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		626613 AGTRA_RAT (1-359): 3.03e-89: 274: 94.71		ARRB1_RAT (1-399): 0: 654: 76.90
+	Hs
		428933 ADRB2_HUMAN (8-341): 5.17e-74: 236: 20.11		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Mm
		669680 AGTRA_MOUSE (1-359): 2.61e-88: 271: 94.43		ARRB1_MOUSE (1-399): 0: 652: 76.90
+	Hs
		827128 CCR5_HUMAN (15-342): 1.52e-84: 261: 28.96		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		685813 APJ_HUMAN (9-356): 5.19e-73: 233: 29.78		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (8-335): 1.09e-73: 235: 20.73		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		685822 OPRD_HUMAN (10-353): 9.69e-69: 221: 27.38		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		827197 MTR1L_HUMAN (8-342): 2.21e-66: 222: 19.76		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		781016 OPRD_HUMAN (10-353): 9.69e-69: 221: 27.38		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		685848 AGTR2_HUMAN (31-311): 4.53e-52: 178: 37.94		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		626815 ACKR3_HUMAN (18-310): 3.06e-46: 162: 32.88		ARRB1_HUMAN (1-407): 0: 661: 76.15