HitPredict

Interactor 1: AGTR1 (P30556)
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Gene: AGTR1

Interactor 2: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	15611106, 17498700
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 418
+	Rn
		626613 AGTRA_RAT (1-359): 3.03e-89: 274: 94.71		ARRB1_RAT (1-418): 0: 707: 99.04
+	Hs
		827128 CCR5_HUMAN (15-342): 1.52e-84: 261: 28.96		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Mm
		669680 AGTRA_MOUSE (1-359): 2.61e-88: 271: 94.43		ARRB1_MOUSE (1-418): 0: 703: 98.57
+	Hs
		827197 MTR1L_HUMAN (8-342): 2.21e-66: 222: 19.76		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		781016 OPRD_HUMAN (10-353): 9.69e-69: 221: 27.38		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		674827 AGTR1_HUMAN (1-359): 5.59e-90: 276: 100.00		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Rn
		626614 AGTRA_RAT (1-359): 3.03e-89: 274: 94.71		ARRB2_RAT (1-407): 0: 616: 75.00
+	Hs
		626815 ACKR3_HUMAN (18-310): 3.06e-46: 162: 32.88		ARRB1_HUMAN (1-418): 0: 716: 100.00
+	Hs
		428933 ADRB2_HUMAN (8-341): 5.17e-74: 236: 20.11		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		685813 APJ_HUMAN (9-356): 5.19e-73: 233: 29.78		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Rn
		663954 Q8VBU7_RAT (8-335): 1.09e-73: 235: 20.73		ARRB2_RAT (1-407): 0: 616: 75.00
+	Hs
		685822 OPRD_HUMAN (10-353): 9.69e-69: 221: 27.38		ARRB2_HUMAN (1-407): 0: 626: 76.15
+	Hs
		685848 AGTR2_HUMAN (31-311): 4.53e-52: 178: 37.94		ARRB2_HUMAN (1-407): 0: 626: 76.15