HitPredict

Interactor 1: AGTR1 (P30556)
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
Gene: AGTR1

Interactor 2: ACE2 (Q9BYF1)
Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]
Gene: ACE2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 0.60 0.595

The method score is based on:

Property Details
Experiments 36564389, 33339432
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003081 - regulation of systemic arterial blood pressure by renin-angiotensin
GO:0005886 - plasma membrane
GO:0016020 - membrane
GO:0019229 - regulation of vasoconstriction
GO:0042127 - regulation of cell population proliferation
and 4 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 359
Hs

1 805
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024