Interactor 1: CLIP1 (P30622)
CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)
Gene: CLIP1

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.932

The method score is based on:

Property Details
Experiments 26638075, 34079125, 35271311, 17828277, 17828275
Identification Methods proximity labelling technology, affinity chromatography technology, isothermal titration calorimetry, x-ray crystallography, static light scattering, surface plasmon resonance, molecular sieving, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CAP_GLY~CAP_GLY, CAP_GLY~CLIP1_ZNF
Common GO terms GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005874 - microtubule
and 8 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1438
Hs

1 1278
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024