HitPredict

Interactor 1: XPO1 (P30822)
Exportin-1 (Chromosome region maintenance protein 1) (Karyopherin-124)
Gene: CRM1

Interactor 2: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	10825193, 11251069, 9636166, 36099418, 26120835, 15769879, 20485264, 23164569
Identification Methods	two hybrid, affinity chromatography technology, pull down, biochemical, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CRM1_C~Ras, CRM1_repeat~Ras, CRM1_repeat_2~Ras, IBN_N~Ras, Ras~Xpo1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Sc			1 219
+	Hs
		162599 XPO1_HUMAN (3-1084): 0: 854: 46.40		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		919301 XPO7_HUMAN (11-1030): 8.18e-147: 469: 13.59		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Dm
		1373317 Q9VRV8_DROME (13-1014): 2.63e-118: 388: 11.22		RANL_DROME (13-219): 2.1e-90: 266: 59.42
+	At
		784987 MOS14_ARATH (10-998): 7.93e-112: 372: 12.33		RAN1_ARATH (1-216): 6.84e-94: 275: 75.58
+	Hs
		919198 TNPO1_HUMAN (21-967): 5.08e-125: 406: 12.09		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	At
		784988 TNPO1_ARATH (13-869): 1.45e-104: 350: 11.52		RAN1_ARATH (1-216): 6.84e-94: 275: 75.58
+	Hs
		155560 TNPO2_HUMAN (21-956): 4.51e-116: 382: 11.98		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		919228 XPO6_HUMAN (8-1040): 1.57e-107: 364: 13.21		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		207921 XPOT_HUMAN (17-1040): 1.69e-106: 357: 16.81		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		297168 IPO13_HUMAN (5-1046): 2.03e-105: 355: 15.86		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		919258 XPO4_HUMAN (6-1025): 4.89e-102: 349: 12.86		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Sp
		292805 XPOT_SCHPO (11-1040): 3.66e-93: 321: 13.74		SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37
+	At
		784985 HASTY_ARATH (8-678): 2.74e-75: 273: 14.72		RAN1_ARATH (1-216): 6.84e-94: 275: 75.58
+	Hs
		914368 XPO5_HUMAN (1-879): 1.9e-81: 291: 13.44		RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17
+	Hs
		919273 XPO5_HUMAN (1-879): 1.9e-81: 291: 13.44		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Sc
		698996 MTR10_YEAST (25-890): 2.39e-75: 270: 14.40		GSP1_YEAST (1-219): 1.49e-79: 239: 100.00
+	Sc
		699022 MTR10_YEAST (25-890): 2.39e-75: 270: 14.40		GSP2_YEAST (1-219): 9.33e-78: 234: 96.82
+	Hs
		207913 XPOT_HUMAN (17-1040): 1.69e-106: 357: 16.81		RAB9A_HUMAN (8-170): 8.21e-28: 106: 31.77
+	Sc
		698755 XPOT_YEAST (13-523): 8.56e-11: 68.3: 14.31		GSP1_YEAST (1-219): 1.49e-79: 239: 100.00
+	Sc
		699000 XPOT_YEAST (13-523): 8.56e-11: 68.3: 14.31		GSP2_YEAST (1-219): 9.33e-78: 234: 96.82