HitPredict

Interactor 1: CCL5 (P30882)
C-C motif chemokine 5 (MuRantes) (SIS-delta) (Small-inducible cytokine A5) (T-cell-specific protein RANTES)
Gene: CCL5

Interactor 2: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	16931600, 15536134, 16707500, 10926836, 22388040
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0034097 - response to cytokine GO:0042803 - protein homodimerization activity GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 91 Mm			1 549
+	Mm
		486360 CCL2_MOUSE (1-91): 3.19e-33: 113: 35.48		TF65_MOUSE (1-549): 0: 662: 100.00
+	Hs
		526567 CCL4_HUMAN (1-91): 3.93e-35: 116: 48.91		TF65_HUMAN (1-549): 0: 631: 87.52
+	Mm
		292678 CCL20_MOUSE (8-90): 8.35e-22: 83.1: 23.53		TF65_MOUSE (1-549): 0: 662: 100.00
+	Hs
		978774 CCL14_HUMAN (1-91): 2.52e-34: 114: 39.79		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		528260 CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		528216 CCL2_HUMAN (1-89): 4.82e-27: 96.6: 34.07		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		943970 X3CL1_HUMAN (8-90): 1.01e-21: 88.9: 25.29		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		134732 CCL22_HUMAN (21-90): 4.73e-22: 83.5: 34.72		TF65_HUMAN (1-549): 0: 631: 87.52
+	Mm
		638438 CCL5_MOUSE (1-91): 5.13e-35: 116: 100.00		NFKB1_MOUSE (6-485): 5.81e-151: 459: 28.96
+	Mm
		486356 CCL2_MOUSE (1-91): 3.19e-33: 113: 35.48		NFKB1_MOUSE (6-485): 5.81e-151: 459: 28.96
+	Hs
		528261 CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22		REL_HUMAN (12-491): 8.06e-158: 465: 42.89
+	Hs
		528259 CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22		RELB_HUMAN (7-453): 8.96e-153: 451: 39.20
+	Hs
		587597 CCL14_HUMAN (1-91): 2.52e-34: 114: 39.79		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Hs
		964508 CCL17_HUMAN (7-89): 1.01e-22: 85.4: 28.57		RELB_HUMAN (7-453): 8.96e-153: 451: 39.20
+	Hs
		587476 CCL11_HUMAN (1-90): 1.32e-27: 97.7: 40.66		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Hs
		134731 CCL22_HUMAN (21-90): 4.73e-22: 83.5: 34.72		RELB_HUMAN (7-453): 8.96e-153: 451: 39.20
+	Hs
		528199 CCL2_HUMAN (1-89): 4.82e-27: 96.6: 34.07		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Hs
		134722 CCL22_HUMAN (21-90): 4.73e-22: 83.5: 34.72		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Hs
		587691 CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Mm
		486364 CCL2_MOUSE (1-91): 3.19e-33: 113: 35.48		NFAT5_MOUSE (6-451): 3.87e-84: 287: 18.63