HitPredict

Interactor 1: DLG1 (P31007)
Disks large 1 tumor suppressor protein (Dlg)
Gene: DLG1

Interactor 2: PRKN (Q7KTX7)
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31)
Gene: park

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.80	0.587

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 970 Dm			1 482
+	Hs
		159120 CSKP_HUMAN (31-379): 3.04e-26: 118: 10.26		PRKN_HUMAN (30-481): 1.03e-111: 340: 41.77
+	Rn
		1144074 CSKP_RAT (31-379): 1.01e-27: 123: 10.87		PRKN_RAT (30-481): 1.56e-109: 334: 41.81
+	Mm
		251109 CSKP_MOUSE (31-379): 3.09e-26: 118: 10.26		PRKN_MOUSE (30-481): 1.45e-111: 339: 41.90
+	Hs
		227141 DLG4_HUMAN (452-657): 1.01e-22: 106: 22.54		PRKN_HUMAN (30-481): 1.03e-111: 340: 41.77
+	Hs
		227429 MPP2_HUMAN (157-536): 2.26e-19: 95.3: 13.20		PRKN_HUMAN (30-481): 1.03e-111: 340: 41.77
+	Hs
		228930 PALS2_HUMAN (173-370): 1.55e-18: 92.2: 16.83		PRKN_HUMAN (30-481): 1.03e-111: 340: 41.77
+	Hs
		159293 CSKP_HUMAN (31-379): 3.04e-26: 118: 10.26		ARI1_HUMAN (230-481): 4e-76: 250: 25.10
+	Hs
		159239 CSKP_HUMAN (31-379): 3.04e-26: 118: 10.26		CUL9_HUMAN (94-475): 7.95e-69: 241: 15.42
+	Hs
		1168519 PALS1_HUMAN (1-506): 1.15e-24: 112: 10.68		RN19B_HUMAN (242-478): 7.06e-60: 210: 22.95
+	Hs
		958841 EM55_HUMAN (152-570): 1.68e-23: 107: 12.80		RNF31_HUMAN (134-467): 7.39e-57: 205: 15.39
+	Mm
		924252 DLG4_MOUSE (452-657): 1.15e-22: 106: 22.54		RL40_MOUSE (30-111): 8.79e-12: 64.3: 41.38