HitPredict

Interactor 1: DLG4 (P31016)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: GRASP (Q8R4T5)
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) (95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein) (PSD-95 PDZ domain-containing protein) (Tamalin)
Gene: Tamalin

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	12586822
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0030165 - PDZ domain binding GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Rn			1 394
+	Hs
		942399 DLG4_HUMAN (1-724): 0: 676: 99.86		SHAN2_HUMAN (17-338): 5.9e-41: 156: 16.72
+	Hs
		942404 DLG4_HUMAN (1-724): 0: 676: 99.86		SHAN1_HUMAN (51-334): 1.21e-36: 144: 18.79
+	Mm
		1143381 DLG4_MOUSE (1-724): 0: 676: 99.45		SHAN2_MOUSE (17-338): 5.34e-35: 139: 17.09
+	Rn
		677807 DLG4_RAT (1-724): 0: 677: 100.00		SHAN1_RAT (51-334): 3.89e-34: 136: 17.50
+	Mm
		88371 DLG4_MOUSE (1-724): 0: 676: 99.45		SHAN1_MOUSE (51-334): 3.75e-34: 136: 18.69
+	Mm
		1112558 DLG4_MOUSE (1-724): 0: 676: 99.45		SNX27_MOUSE (98-230): 1.21e-33: 133: 24.82
+	Mm
		1143518 DLG4_MOUSE (1-724): 0: 676: 99.45		MAGI3_MOUSE (69-283): 2.33e-28: 119: 19.46
+	Rn
		677805 DLG4_RAT (1-724): 0: 677: 100.00		NHRF3_RAT (46-360): 1.34e-20: 95.6: 15.27
+	Mm
		1115938 DLG4_MOUSE (1-724): 0: 676: 99.45		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Mm
		936801 DLG4_MOUSE (1-724): 0: 676: 99.45		NHRF1_MOUSE (95-253): 2.44e-10: 63.3: 23.17
+	Mm
		1115995 DLG1_MOUSE (5-724): 0: 577: 69.12		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Rn
		1144072 CSKP_RAT (6-203): 2.58e-19: 95.1: 15.08		GRASP_RAT (1-394): 9.35e-106: 318: 100.00
+	Rn
		1144361 DLG2_RAT (245-475): 1.18e-16: 86.3: 22.36		SHAN1_RAT (51-334): 3.89e-34: 136: 17.50
+	Mm
		936433 EM55_MOUSE (5-325): 4.95e-21: 99: 14.85		WHRN_MOUSE (54-241): 1.54e-16: 83.6: 17.37
+	Mm
		1116170 MPP2_MOUSE (2-199): 2.56e-18: 90.9: 18.05		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Mm
		1116062 DLG2_MOUSE (245-475): 1.18e-16: 86.3: 22.36		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Hs
		1132886 MPP7_HUMAN (51-319): 1.68e-17: 88.6: 12.73		SNX27_HUMAN (106-208): 7.08e-13: 71.8: 25.93
+	Hs
		1232496 PALS1_HUMAN (22-322): 4.05e-17: 87.8: 11.33		MAGI1_HUMAN (10-226): 1.2e-09: 62.3: 13.36