Interactor 1: METK2 (P31153)
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
Gene: MAT2A
Interactor 2: METK2 (P31153)
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
Gene: MAT2A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.80 | 1.00 | 0.898 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 27548429, 32296183, unassigned1304 |
| Identification Methods | two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | S-AdoMet_synt_C~S-AdoMet_synt_C, S-AdoMet_synt_C~S-AdoMet_synt_M, S-AdoMet_synt_C~S-AdoMet_synt_N, S-AdoMet_synt_M~S-AdoMet_synt_M, S-AdoMet_synt_M~S-AdoMet_synt_N, S-AdoMet_synt_N~S-AdoMet_synt_N |
| Common GO terms | GO:0004478 - methionine adenosyltransferase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006556 - S-adenosylmethionine biosynthetic process GO:0006730 - one-carbon metabolic process and 6 others more... |
| Homologous interactions | 15 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
