Interactor 1: SUH (P31266)
Recombining binding protein suppressor of hairless (J kappa-recombination signal-binding protein) (RBP-J kappa)
Gene: Rbpj

Interactor 2: NOTC1 (Q01705)
Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: Notch1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 17526737, 17210915, 11518718, 8749394, 18832173, 22258620
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~BTD, Ank_2~LAG1-DNAbind, Ank_2~TIG_SUH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001837 - epithelial to mesenchymal transition
GO:0001947 - heart looping
GO:0002193 - MAML1-RBP-Jkappa- ICN1 complex
and 37 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 526
Mm

1 2531
+ Hs
+ Mm
+ Hs
+ Dm
+ Mm
+ Mm
+ Hs
+ Dm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024