HitPredict

Interactor 1: HXC8 (P31273)
Homeobox protein Hox-C8 (Homeobox protein Hox-3A)
Gene: HOXC8

Interactor 2: PAX5 (Q02548)
Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
Gene: PAX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 391
+	Hs
		641327 HXC8_HUMAN (1-242): 4.21e-59: 188: 100.00		PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21
+	Hs
		678904 HXC8_HUMAN (1-242): 4.21e-59: 188: 100.00		PAX8_HUMAN (12-389): 2.17e-67: 221: 49.00
+	Mm
		192281 ALX4_MOUSE (11-240): 1.99e-32: 123: 17.52		PAX3_MOUSE (7-380): 1.64e-80: 256: 34.62
+	Dm
		447431 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		GSBN_DROME (15-354): 6.83e-71: 230: 31.18
+	Dm
		415559 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		PRD_DROME (7-381): 9.77e-69: 229: 31.87
+	Dm
		447432 UBX_DROME (16-210): 1.45e-33: 126: 30.69		GSBN_DROME (15-354): 6.83e-71: 230: 31.18
+	Dm
		668253 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		Q59DN8_DROME (13-217): 6.72e-51: 184: 59.02
+	Hs
		678981 HXC8_HUMAN (1-242): 4.21e-59: 188: 100.00		HESX1_HUMAN (116-293): 2.15e-33: 125: 12.92
+	Dm
		620024 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		POXM_DROME (10-193): 7.81e-45: 160: 56.52
+	Dm
		447322 SCR_DROME (113-209): 5.7e-38: 138: 50.00		POXM_DROME (10-193): 7.81e-45: 160: 56.52
+	Dm
		620032 UBX_DROME (16-210): 1.45e-33: 126: 30.69		POXM_DROME (10-193): 7.81e-45: 160: 56.52
+	Mm
		192291 ALX4_MOUSE (11-240): 1.99e-32: 123: 17.52		PRRX1_MOUSE (136-344): 3.14e-36: 134: 17.67
+	Mm
		192275 ALX4_MOUSE (11-240): 1.99e-32: 123: 17.52		ALX4_MOUSE (138-368): 4.56e-33: 129: 17.08
+	Hs
		1077278 ALX1_HUMAN (31-240): 9.04e-35: 128: 15.57		ALX4_HUMAN (139-383): 2.07e-30: 122: 15.29
+	Dm
		185806 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		PAX6_DROME (111-381): 2.51e-22: 101: 15.33
+	Dm
		185807 HMPB_DROME (34-231): 3.02e-36: 137: 29.90		PAX6_DROME (111-381): 2.51e-22: 101: 15.33
+	Dm
		668243 ABDA_DROME (26-241): 1.84e-37: 140: 33.80		AL_DROME (182-387): 1.39e-21: 97.3: 20.25
+	Dm
		185813 UBX_DROME (16-210): 1.45e-33: 126: 30.69		PAX6_DROME (111-381): 2.51e-22: 101: 15.33
+	Dm
		185797 ANTP_DROME (23-222): 2.07e-33: 125: 33.96		PAX6_DROME (111-381): 2.51e-22: 101: 15.33
+	Dm
		949988 UBX_DROME (16-210): 1.45e-33: 126: 30.69		AL_DROME (182-387): 1.39e-21: 97.3: 20.25