HitPredict

Interactor 1: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	35140242, 19250647
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 770
+	Hs
		679098 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		213321 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		679097 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		213323 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		213322 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980675 EMX2_HUMAN (82-290): 1.39e-36: 133: 28.11		TLE2_HUMAN (1-770): 2e-150: 458: 64.85
+	Dm
		558366 UBX_DROME (65-265): 4.1e-33: 128: 23.83		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		679101 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Mm
		590280 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		GBB1_MOUSE (474-767): 2.56e-99: 312: 20.46
+	Hs
		213326 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		447242 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		137664 HM19_CAEEL (194-307): 1.11e-35: 130: 35.65		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Hs
		245566 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		213284 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		245638 NANOG_HUMAN (133-316): 2.34e-38: 140: 25.89		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		211773 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		590275 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		WDR5_MOUSE (655-769): 2.57e-36: 141: 21.37
+	Hs
		903141 PO5F1_HUMAN (31-327): 1.93e-33: 128: 17.00		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		211820 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		447294 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		GBB4_HUMAN (686-769): 9.66e-14: 75.2: 18.82