HitPredict

Interactor 1: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 772
+	Hs
		679096 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		679098 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		213322 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		211839 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		213321 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		213323 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		211837 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		211840 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		980675 EMX2_HUMAN (82-290): 1.39e-36: 133: 28.11		TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10
+	Hs
		211838 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10
+	Dm
		558366 UBX_DROME (65-265): 4.1e-33: 128: 23.83		GROU_DROME (1-772): 4.17e-136: 421: 57.20
+	Hs
		679101 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		213326 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		447242 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Ce
		137664 HM19_CAEEL (194-307): 1.11e-35: 130: 35.65		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Hs
		447294 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		GBB4_HUMAN (441-646): 3.79e-39: 150: 20.00
+	Mm
		590280 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		GBB1_MOUSE (567-770): 1.63e-38: 148: 17.62
+	Mm
		590275 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		WDR5_MOUSE (284-560): 2.42e-32: 130: 9.12
+	Hs
		903141 PO5F1_HUMAN (31-327): 1.93e-33: 128: 17.00		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12
+	Hs
		211820 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12