HitPredict

Interactor 1: TLX1 (P31314)
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)
Gene: TLX1

Interactor 2: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 773
+	Hs
		679096 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		213323 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Hs
		679097 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		213321 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		213322 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		980675 EMX2_HUMAN (82-290): 1.39e-36: 133: 28.11		TLE2_HUMAN (8-773): 3.63e-157: 476: 65.19
+	Dm
		558366 UBX_DROME (65-265): 4.1e-33: 128: 23.83		GROU_DROME (8-773): 1.23e-144: 443: 59.14
+	Hs
		679101 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Ce
		137664 HM19_CAEEL (194-307): 1.11e-35: 130: 35.65		UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86
+	Hs
		213326 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		447242 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		245566 TLX1_HUMAN (1-330): 1.72e-60: 198: 100.00		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		213284 TLX2_HUMAN (4-327): 2e-39: 142: 50.89		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		245638 NANOG_HUMAN (133-316): 2.34e-38: 140: 25.89		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		211773 TLX3_HUMAN (11-325): 9.96e-34: 127: 47.94		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		447294 HXB5_HUMAN (53-273): 4.3e-39: 140: 22.22		GBB4_HUMAN (439-647): 2.61e-43: 161: 19.72
+	Mm
		590275 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		WDR5_MOUSE (658-772): 3.81e-36: 141: 21.37
+	Hs
		903141 PO5F1_HUMAN (31-327): 1.93e-33: 128: 17.00		WDR5_HUMAN (658-772): 3.81e-36: 141: 21.37
+	Hs
		929665 NANOG_HUMAN (133-316): 2.34e-38: 140: 25.89		RACK1_HUMAN (473-675): 5.84e-12: 69.3: 25.37
+	Mm
		590280 PO5F1_MOUSE (32-327): 1.17e-33: 128: 15.15		GBB1_MOUSE (689-772): 7.32e-15: 78.6: 17.65